And the answers.
1. What game is the line from?
The Elder Scrolls IV: Shivering Isles. The official expansion to The Elder Scrolls IV: Oblivion.
2. Who is speaking?
Haskill, the chamberlain of Sheogorath.
3. The name of the voice actor doing the performance.
Jeff Baker. He was also the voice of the Imperials in Morrowind.